Search results for "Thyroid-Associated Ophthalmopathy"
showing 3 items of 3 documents
Endokrine Orbitopathie 1998
1998
Die haufigste extrathyreoidale Manifestation der autoimmunen Thyreopathie ist die endokrine Orbitopathie. Das Charakteristikum dieser Autoimmunerkrankung ist die entzundliche Volumenzunahme des peri- und retrobulbaren Gewebes, die zur klinischen Symptomatik nichtinfiltrativer Lidaffektionen, Protrusio bulbi, Augenmuskelparesen und bis hin zum Visusverlust fuhren kann. Die pathologischen Veranderungen der endokrinen Orbitopathie sind gekennzeichnet durch immunologisch vermittelte Entzundungsreaktionen im Retrobulbarraum, in deren Verlaufes zur lymphozytaren Infiltration und Einlagerung von Glykosaminoglykanen in das orbitale Muskel-, Binde- und Fettgewebe kommt. Trotz verschiedener neuer dia…
Sinusitis in Thyroid Associated Ophthalmopathy
1993
In 19 patients with thyroid associated ophthalmopathy undergoing orbital decompression, histologic examination of paranasal sinus mucosa revealed moderate to severe inflammatory alterations in all patients. Only 2/19 patients had a history of chronic sinusitis. In 4/19 patients, mucosal abnormalities of the paranasal sinuses were found on preoperative computed tomography CT scans. Postoperatively, 10/19 patients developed purulent sinusitis. It is suggested that patients suffering from thyroid associated ophthalmopathy have an increased incidence of histologically detectable inflammatory changes of paranasal sinus mucosa. Because of preexisting mucosal inflammation, these patients are pron…
New imaging procedures in thyroid-associated ophthalmopathy
1996
Lymphocytic and other mononuclear cell infiltrations of the retrobulbar space are observed in thyroid-associated ophthalmopathy (TAO). The identification of somatostatin receptors on lymphocytes has provided a rationale for receptor-imaging with the radiolabeled somatostatin analog Octreotide in TAO. Furthermore, previous investigations have shown that quantitative magnetic resonance imaging (MRI) allows non-invasive detection of acute inflammatory changes in extraocular muscles. Therefore, in patients with TAO and controls, scans of the orbits were obtained at 4h and 24h after i.v. injection of the radionuclide and orbital MRI was performed. Compared to controls, patients with TAO showed a…